Статьи за последние 2 года

Competing Role of Water in Inclusion of Indomethacin and Volatile Organic Compounds by Native Cyclodextrins / Osel'skaya V. Y., Gatiatulin A. K., Klimovitskii A. E., Ziganshin M. A., Gorbatchuk V. V. // МГЦ: Макрогетероциклы.— 2022 т. 15 № 3.— C. 174-185.— английский

Источник:   - Выпуск сериального издания ( 1 )   Автор:   - Персоналии ( 5 )

Постоянная ссылка (СИД2) J2094808262 Название Competing Role of Water in Inclusion of Indomethacin and Volatile Organic Compounds by Native Cyclodextrins Автор Osel'skaya V. Y. Автор Gatiatulin A. K. Автор Klimovitskii A. E. Автор Ziganshin M. A. Автор Gorbatchuk V. V. Источник МГЦ: Макрогетероциклы Страницы/Объём 174-185 Сокращ. назв. источника МГЦ: Макрогетероциклы Год 2022 Том 15 Номер 3 Адрес в Интернет http://elibrary.ru/item.asp?id=50006199 Постоянная ссылка (СИД) J20948082 Ключевые слова (авторские) Inclusion Место хранения Удаленный доступ. Эл. регистр. НЭБ Дата регистрации в ВИНИТИ 04.01.2023 Язык текста английский Аннотация The hydration was found to reduce an efficiency of drug encapsulation by native cyclodextrins (CDs) when water is added above a certain threshold level. The hydration water competes with indomethacin for solid-phase inclusion in γ-cyclodextrin (γCD) and β-cyclodextrin (βCD) with an increase of water contents to the saturation level. No competing effect was observed for α-cyclodextrin (αCD) with this drug. The hydration effect for indomethacin correlates with the influence of hydration water on inclusion of volatile organic guests by native CDs. For these guests and γCD, the competing hydration effect was estimated also by determination of vapor sorption isotherms and was found higher than that for βCD but in most cases lower than such effect for αCD. The inclusion affinity and capacity of dried γCD for water and organic guests were determined and a significant size exclusion effect was observed, which contributes to the water-guest competition. The ratio between competing and activation roles of water for the studied three native cyclodextrins correlates with the parameters of their unit cells in hydrates and in dried state Тематический раздел Химия